BDBM272574 US10065963, Compound 32d::US10376513, Example 348::US10646492, Example 347::US10675284, Example 32d::US9932341, Example 348

SMILES CCOc1c(cc(Cl)c(F)c1[C@H]1CNC(=O)C1)[C@H](C)n1nc(C)c2c(N)ncnc12

InChI Key InChIKey=ZQPDJCIXJHUERQ-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 272574   

LigandPNGBDBM272574(US10065963, Compound 32d | US9932341, Example 348 ...)
Affinity DataIC50: 32nMpH: 6.7 T: 2°CAssay Description:[γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2018
Entry Details
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LigandPNGBDBM272574(US10065963, Compound 32d | US9932341, Example 348 ...)
Affinity DataIC50: 125nMpH: 6.7 T: 2°CAssay Description:[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/18/2019
Entry Details
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LigandPNGBDBM272574(US10065963, Compound 32d | US9932341, Example 348 ...)
Affinity DataIC50: 125nMAssay Description:The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 uL. Inhibitors wer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2020
Entry Details
Go to US Patent

LigandPNGBDBM272574(US10065963, Compound 32d | US9932341, Example 348 ...)
Affinity DataIC50: 125nMAssay Description:[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details
Go to US Patent

LigandPNGBDBM272574(US10065963, Compound 32d | US9932341, Example 348 ...)
Affinity DataIC50: 10nMAssay Description:The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 uL. Inhibitors wer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/25/2021
Entry Details
Go to US Patent

LigandPNGBDBM272574(US10065963, Compound 32d | US9932341, Example 348 ...)
Affinity DataIC50: 125nMAssay Description:[γ-33P]ATP (10 mCi/mL) was purchased from Perking Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (P...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2021
Entry Details
Go to US Patent