BDBM27214 2,2,2-trichloroethyl N-methyl-N-[(1R,2S,5S,6S,9R,12S,13R,16S)-6,7,13-trimethyl-7-azapentacyclo[10.8.0.0^{2,9}.0^{5,9}.0^{13,18}]icos-18-en-16-yl]carbamate::Conessine analogue, 9

SMILES [H][C@@]1(C)N(C)C[C@]23CC[C@@]4([H])[C@@]([H])(CC=C5C[C@H](CC[C@]45C)N(C)C(=O)OCC(Cl)(Cl)Cl)[C@]2([H])CC[C@]13[H]

InChI Key InChIKey=DINDUEXSAMHHDB-UHFFFAOYSA-N

Data  4 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 27214   

TargetHistamine H3 receptor(Rat)
Abbott Laboratories

LigandPNGBDBM27214(2,2,2-trichloroethyl N-methyl-N-[(1R,2S,5S,6S,9R,1...)
Affinity DataKi:  7.91nMAssay Description:Competition radioligand binding assays were performed with increasing concentrations of test compound in the presence of [3H]ligand. All binding reac...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2009
Entry Details Article
PubMed
TargetHistamine H3 receptor(Rat)
Abbott Laboratories

LigandPNGBDBM27214(2,2,2-trichloroethyl N-methyl-N-[(1R,2S,5S,6S,9R,1...)
Affinity DataKi:  7.91nMAssay Description:Displacement of [3H]N-alpha methyl histamine from rat cortical membrane histamine H3 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
Abbott Laboratories

LigandPNGBDBM27214(2,2,2-trichloroethyl N-methyl-N-[(1R,2S,5S,6S,9R,1...)
Affinity DataKi:  19.7nM ΔG°:  -10.5kcal/molepH: 7.4 T: 2°CAssay Description:Competition radioligand binding assays were performed with increasing concentrations of test compound in the presence of [3H]ligand. All binding reac...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2009
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
Abbott Laboratories

LigandPNGBDBM27214(2,2,2-trichloroethyl N-methyl-N-[(1R,2S,5S,6S,9R,1...)
Affinity DataKi:  19.7nMAssay Description:Displacement of [3H]N-alpha methyl histamine from human cloned histamine H3 receptor expressed in C6 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed