BDBM271685 US10065941, Compound R-019::US9732060, Compound R-019

SMILES C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3cnccn3)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O

InChI Key InChIKey=HAEGJGWAGZSLCY-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 271685   

TargetP2X purinoceptor 3(Human)
Shionogi

US Patent
LigandPNGBDBM271685(US10065941, Compound R-019 | US9732060, Compound R...)
Affinity DataIC50: 6nMpH: 7.5Assay Description:Stably expressing cell line (C6BU-1 cell transfected with human P2X3 receptor gene (GenBank accession number Y07683) was used. The cells were seeded ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2018
Entry Details
Go to US Patent

TargetP2X purinoceptor 3(Rat)
Shionogi

US Patent
LigandPNGBDBM271685(US10065941, Compound R-019 | US9732060, Compound R...)
Affinity DataIC50: 8nMAssay Description:Rat P2X3 receptor gene (GenBank accession number NM_031075) was expressed in C6BU-1 cell. The C6BU-1 cells were seeded in a 96-well microtiter plate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2018
Entry Details
Go to US Patent

TargetP2X purinoceptor 3(Human)
Shionogi

US Patent
LigandPNGBDBM271685(US10065941, Compound R-019 | US9732060, Compound R...)
Affinity DataIC50: 6nMAssay Description:Stably expressing cell line (C6BU-1 cell transfected with human P2X3 receptor gene (GenBank accession number Y07683) was used. The cells were seeded ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2019
Entry Details
Go to US Patent

TargetP2X purinoceptor 3(Human)
Shionogi

US Patent
LigandPNGBDBM271685(US10065941, Compound R-019 | US9732060, Compound R...)
Affinity DataIC50: 5.80nMAssay Description:Antagonist activity at P2X3 receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2023
Entry Details Article
PubMed