BDBM271385 US10064861, Compound 38

SMILES Oc1ccc-2cc1CCn1c(NC(=O)c3cccc(Cn4nc-2ccc4=O)c3)nc2ccccc12

InChI Key InChIKey=FFBJVDYYHMCFMC-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 271385   

TargetInterleukin-1 receptor-associated kinase 1(Human)
Merck Patent

US Patent
LigandPNGBDBM271385(US10064861, Compound 38)
Affinity DataIC50: 100nMpH: 7.0Assay Description:IRAK1 is a human purified recombinant enzyme (His-TEV-IRAK1 (194-712)) In this assay, IRAK-1 hydrolyses ATP and autophosphorylates.Measurement of IRA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2018
Entry Details
Go to US Patent

TargetInterleukin-1 receptor-associated kinase 4(Human)
Merck Patent

US Patent
LigandPNGBDBM271385(US10064861, Compound 38)
Affinity DataIC50: 100nMpH: 7.0Assay Description:IRAK4 is a human purified recombinant enzyme (His-TEV-IRAK1 (194-712) IRAK4 hydrolyses ATP, autophosphorylates and phosphorylates a Serine/Threonine ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2018
Entry Details
Go to US Patent