BDBM271372 US10064861, Compound 27

SMILES O=C1Nc2nc3cc(CN4CCOCC4)ccc3n2Cc2cccc(c2)-c2ccc(=O)n(Cc3cccc1c3)n2

InChI Key InChIKey=SFNBUPVUSJJGTO-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 271372   

TargetInterleukin-1 receptor-associated kinase 1(Human)
Merck Patent

US Patent
LigandPNGBDBM271372(US10064861, Compound 27)
Affinity DataIC50: 100nMpH: 7.0Assay Description:IRAK1 is a human purified recombinant enzyme (His-TEV-IRAK1 (194-712)) In this assay, IRAK-1 hydrolyses ATP and autophosphorylates.Measurement of IRA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2018
Entry Details
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TargetInterleukin-1 receptor-associated kinase 4(Human)
Merck Patent

US Patent
LigandPNGBDBM271372(US10064861, Compound 27)
Affinity DataIC50: 100nMpH: 7.0Assay Description:IRAK4 is a human purified recombinant enzyme (His-TEV-IRAK1 (194-712) IRAK4 hydrolyses ATP, autophosphorylates and phosphorylates a Serine/Threonine ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2018
Entry Details
Go to US Patent