BDBM271244 US10059720, Example 59::US10975091, Example 59

SMILES CCC(C)(C)CCOc1ccnc(C[C@@](O)([C@@H](N)CC(C)C)C(O)=O)c1

InChI Key InChIKey=KPBRFJVSPLIUKF-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 271244   

TargetLeucyl-cystinyl aminopeptidase(Rat)
Astellas Pharma

US Patent
LigandPNGBDBM271244(US10059720, Example 59 | US10975091, Example 59)
Affinity DataIC50: 1.70nMAssay Description:Rat epididymal fat pads were homogenized and subjected to ultracentrifugation at 100,000×g for 30 minutes to obtain microsomes containing IRAP. The m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2018
Entry Details
Go to US Patent

TargetLeucyl-cystinyl aminopeptidase(Human)
Astellas Pharma

US Patent
LigandPNGBDBM271244(US10059720, Example 59 | US10975091, Example 59)
Affinity DataIC50: 4.40nMAssay Description:HEK293 cells forced to transiently express hP-LAP (J Biol Chem 1996; 271: 56-61) were prepared by lipofection, homogenized, and then subjected to ult...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2018
Entry Details
Go to US Patent

TargetLeucyl-cystinyl aminopeptidase(Rat)
Astellas Pharma

US Patent
LigandPNGBDBM271244(US10059720, Example 59 | US10975091, Example 59)
Affinity DataIC50: 1.70nMAssay Description:IRAP: Rat epididymal fat pads were homogenized and subjected to ultracentrifugation at 100,000×g for 30 minutes to obtain microsomes containing IRAP....More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2021
Entry Details
Go to US Patent

TargetLeucyl-cystinyl aminopeptidase(Human)
Astellas Pharma

US Patent
LigandPNGBDBM271244(US10059720, Example 59 | US10975091, Example 59)
Affinity DataIC50: 4.40nMAssay Description:hP-LAP: HEK293 cells forced to transiently express hP-LAP were prepared by lipofection, homogenized, and then subjected to ultracentrifugation at 100...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2021
Entry Details
Go to US Patent