BDBM27087 3-cyclopropyl-1-{3-[5-(morpholin-4-ylmethyl)-1H-1,3-benzodiazol-2-yl]-1H-pyrazol-4-yl}urea::pyrazole-benzimidazole urea analogue, 16

SMILES O=C(NC1CC1)Nc1c[nH]nc1-c1nc2ccc(CN3CCOCC3)cc2[nH]1

InChI Key InChIKey=LOLPPWBBNUVNQZ-UHFFFAOYSA-N

Data  10 IC50  2 Other

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 27087   

TargetAurora kinase A(Human)
Astex

LigandPNGBDBM27087(3-cyclopropyl-1-{3-[5-(morpholin-4-ylmethyl)-1H-1,...)
Affinity DatapH: 7.0 T: 2°CAssay Description:Assays for Aurora kinase was performed in a DELFIA format. Aurora enzyme was incubated with test compound and cross-tide substrate in the reaction bu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2009
Entry Details Article
PubMed
TargetAurora kinase B(Human)
Astex

LigandPNGBDBM27087(3-cyclopropyl-1-{3-[5-(morpholin-4-ylmethyl)-1H-1,...)
Affinity DatapH: 8.5 T: 2°CAssay Description:Assays for Aurora kinase was performed in a DELFIA format. Aurora enzyme was incubated with test compound and cross-tide substrate in the reaction bu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2009
Entry Details Article
PubMed
LigandPNGBDBM27087(3-cyclopropyl-1-{3-[5-(morpholin-4-ylmethyl)-1H-1,...)
Affinity DataIC50: 1.70E+3nMAssay Description:Assays for Aurora kinase was performed in a DELFIA format. Aurora enzyme was incubated with test compound and cross-tide substrate in the reaction bu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2009
Entry Details Article
PubMed
LigandPNGBDBM27087(3-cyclopropyl-1-{3-[5-(morpholin-4-ylmethyl)-1H-1,...)
Affinity DataIC50: 510nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2009
Entry Details Article
PubMed
TargetAurora kinase B(Human)
Astex

LigandPNGBDBM27087(3-cyclopropyl-1-{3-[5-(morpholin-4-ylmethyl)-1H-1,...)
Affinity DataIC50: 2.70nMAssay Description:Inhibition of aurora B (unknown origin) by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Astex

LigandPNGBDBM27087(3-cyclopropyl-1-{3-[5-(morpholin-4-ylmethyl)-1H-1,...)
Affinity DataIC50: 3.30nMAssay Description:Inhibition of aurora A (unknown origin) after 1 hr by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Astex

LigandPNGBDBM27087(3-cyclopropyl-1-{3-[5-(morpholin-4-ylmethyl)-1H-1,...)
Affinity DataIC50: 3nMAssay Description:Inhibition of aurora A kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2012
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM27087(3-cyclopropyl-1-{3-[5-(morpholin-4-ylmethyl)-1H-1,...)
Affinity DataIC50: 10nMAssay Description:Inhibition of Flt3More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2012
Entry Details Article
PubMed
TargetTyrosine-protein kinase ABL1(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM27087(3-cyclopropyl-1-{3-[5-(morpholin-4-ylmethyl)-1H-1,...)
Affinity DataIC50: 4nMAssay Description:Inhibition of Abl T315I mutantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2012
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM27087(3-cyclopropyl-1-{3-[5-(morpholin-4-ylmethyl)-1H-1,...)
Affinity DataIC50: 1nMAssay Description:Binding affinity to Jak2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2012
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM27087(3-cyclopropyl-1-{3-[5-(morpholin-4-ylmethyl)-1H-1,...)
Affinity DataIC50: 1nMAssay Description:Binding affinity to Jak3More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2012
Entry Details Article
PubMed
TargetAurora kinase B(Human)
Astex

LigandPNGBDBM27087(3-cyclopropyl-1-{3-[5-(morpholin-4-ylmethyl)-1H-1,...)
Affinity DataIC50: 3nMAssay Description:Inhibition of aurora B kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2012
Entry Details Article
PubMed