BDBM270603 (S)-8-chloro-N4-(3- chloro-4- fluorophenyl)-N6- (phenyl(1-(piperidin- 4-yl)-1H-1,2,3- triazol-4- yl)methyl) quinazoline- 4,6-diamine::US10059695, II-9::US10577352, Compound II-9

SMILES Fc1ccc(Nc2ncnc3c(Cl)cc(N[C@H](c4cn(nn4)C4CCNCC4)c4ccccc4)cc23)cc1Cl

InChI Key InChIKey=KZHPXNUBBKSPPG-UHFFFAOYSA-N

Data  2 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 270603   

TargetEpidermal growth factor receptor(Human)
Gilead Sciences

US Patent
LigandPNGBDBM270603((S)-8-chloro-N4-(3- chloro-4- fluorophenyl)-N6- (p...)
Affinity DataIC50: 8.30nMpH: 7.0 T: 2°CAssay Description:EGFR activity was measured using KinEASE (Cisbio), a time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay. In this assay, EGFR-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2018
Entry Details
Go to US Patent

TargetEpidermal growth factor receptor(Human)
Gilead Sciences

US Patent
LigandPNGBDBM270603((S)-8-chloro-N4-(3- chloro-4- fluorophenyl)-N6- (p...)
Affinity DataEC50:  337nMpH: 7.0 T: 2°CAssay Description:EGFR activity was measured using KinEASE (Cisbio), a time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay. In this assay, EGFR-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2018
Entry Details
Go to US Patent

TargetEpidermal growth factor receptor(Human)
Gilead Sciences

US Patent
LigandPNGBDBM270603((S)-8-chloro-N4-(3- chloro-4- fluorophenyl)-N6- (p...)
Affinity DataIC50: 8.30nMAssay Description:EGFR activity was measured using KinEASE (Cisbio), a time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay. In this assay, EGFR-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2020
Entry Details
Go to US Patent

TargetEpidermal growth factor receptor(Human)
Gilead Sciences

US Patent
LigandPNGBDBM270603((S)-8-chloro-N4-(3- chloro-4- fluorophenyl)-N6- (p...)
Affinity DataEC50:  337nMAssay Description:EGFR activity was measured using KinEASE (Cisbio), a time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay. In this assay, EGFR-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2020
Entry Details
Go to US Patent