BDBM270592 (S)-6-(((1-(1- (difluoromethyl) cyclopropyl)-1H-1,2,3- triazol-4-yl)(2- methyl-1-oxo-1,2- dihydroisoquinolin- 5-yl)methyl)amino)- 4- (neopentylamino) quinazoline-8- carbonitrile::US10059695, I-24::US10577352, Compound I-24

SMILES Cn1ccc2c(cccc2c1=O)[C@H](Nc1cc(C#N)c2ncnc(NCC(C)(C)C)c2c1)c1cn(nn1)C1(CC1)C(F)F

InChI Key InChIKey=ZLTUHAMWJNCZRE-UHFFFAOYSA-N

Data  2 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 270592   

TargetEpidermal growth factor receptor(Human)
Gilead Sciences

US Patent
LigandPNGBDBM270592((S)-6-(((1-(1- (difluoromethyl) cyclopropyl)-1H-1,...)
Affinity DataIC50: 1.20nMpH: 7.0 T: 2°CAssay Description:EGFR activity was measured using KinEASE (Cisbio), a time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay. In this assay, EGFR-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2018
Entry Details
Go to US Patent

TargetEpidermal growth factor receptor(Human)
Gilead Sciences

US Patent
LigandPNGBDBM270592((S)-6-(((1-(1- (difluoromethyl) cyclopropyl)-1H-1,...)
Affinity DataEC50:  11.3nMpH: 7.0 T: 2°CAssay Description:EGFR activity was measured using KinEASE (Cisbio), a time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay. In this assay, EGFR-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2018
Entry Details
Go to US Patent

TargetEpidermal growth factor receptor(Human)
Gilead Sciences

US Patent
LigandPNGBDBM270592((S)-6-(((1-(1- (difluoromethyl) cyclopropyl)-1H-1,...)
Affinity DataIC50: 1.20nMAssay Description:EGFR activity was measured using KinEASE (Cisbio), a time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay. In this assay, EGFR-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2020
Entry Details
Go to US Patent

TargetEpidermal growth factor receptor(Human)
Gilead Sciences

US Patent
LigandPNGBDBM270592((S)-6-(((1-(1- (difluoromethyl) cyclopropyl)-1H-1,...)
Affinity DataEC50:  11.3nMAssay Description:EGFR activity was measured using KinEASE (Cisbio), a time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay. In this assay, EGFR-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2020
Entry Details
Go to US Patent