BDBM270572 N6-((S)-(1- cyclopropyl-1H- 1,2,3-triazol-4-yl)(4- fluorophenyl)methyl- d)-N4-((R)-1- phenylpropyl) quinazoline- 4,6-diamine::US10059695, I-4::US10577352, Compound I-4

SMILES CC[C@@H](Nc1ncnc2ccc(NC(c3cn(nn3)C3CC3)c3ccc(F)cc3)cc12)c1ccccc1

InChI Key InChIKey=ZTUABMSJXUHFJK-UHFFFAOYSA-N

Data  2 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 270572   

TargetEpidermal growth factor receptor(Human)
Gilead Sciences

US Patent
LigandPNGBDBM270572(N6-((S)-(1- cyclopropyl-1H- 1,2,3-triazol-4-yl)(4-...)
Affinity DataIC50: 43nMpH: 7.0 T: 2°CAssay Description:EGFR activity was measured using KinEASE (Cisbio), a time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay. In this assay, EGFR-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2018
Entry Details
Go to US Patent

TargetEpidermal growth factor receptor(Human)
Gilead Sciences

US Patent
LigandPNGBDBM270572(N6-((S)-(1- cyclopropyl-1H- 1,2,3-triazol-4-yl)(4-...)
Affinity DataEC50:  796nMpH: 7.0 T: 2°CAssay Description:EGFR activity was measured using KinEASE (Cisbio), a time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay. In this assay, EGFR-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2018
Entry Details
Go to US Patent

TargetEpidermal growth factor receptor(Human)
Gilead Sciences

US Patent
LigandPNGBDBM270572(N6-((S)-(1- cyclopropyl-1H- 1,2,3-triazol-4-yl)(4-...)
Affinity DataIC50: 43nMAssay Description:EGFR activity was measured using KinEASE (Cisbio), a time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay. In this assay, EGFR-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2020
Entry Details
Go to US Patent

TargetEpidermal growth factor receptor(Human)
Gilead Sciences

US Patent
LigandPNGBDBM270572(N6-((S)-(1- cyclopropyl-1H- 1,2,3-triazol-4-yl)(4-...)
Affinity DataEC50:  796nMAssay Description:EGFR activity was measured using KinEASE (Cisbio), a time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay. In this assay, EGFR-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2020
Entry Details
Go to US Patent