BDBM27009 ketoamide derived inhibitor, 33::tert-butyl N-[(2S)-1-[(1R,2S,5S)-2-{[(2S)-1-carbamoyl-1-oxooct-7-en-2-yl]carbamoyl}-6,6-dimethyl-3-azabicyclo[3.1.0]hexan-3-yl]-1-oxooct-7-en-2-yl]carbamate

SMILES CC(C)(C)OC(=O)N[C@@H](CCCCC=C)C(=O)N1C[C@H]2[C@@H]([C@H]1C(=O)N[C@@H](CCCCC=C)C(=O)C(N)=O)C2(C)C

InChI Key InChIKey=OFBFPNVYRBBLFL-UHFFFAOYSA-N

Data  1 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 27009   

TargetGenome polyprotein(HCV)
Schering-Plough Research Institute

LigandPNGBDBM27009(tert-butyl N-[(2S)-1-[(1R,2S,5S)-2-{[(2S)-1-carbam...)
Affinity DataKi:  250nM ΔG°:  -9.15kcal/molepH: 6.5 T: 2°CAssay Description:Proteolytic cleavage of the ester linkage between the Nva (L-norvaline) and the chromophore (PAP) was monitored for change in absorbance at 370 nm. I...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2009
Entry Details Article
PubMed