BDBM26947 8-(4,4-dimethyl-1,2,3,4-tetrahydronaphthalen-1-yl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one::CHEMBL239822::spiropiperidine analogue, 3

SMILES CC1(C)CCC(N2CCC3(CC2)N(CNC3=O)c2ccccc2)c2ccccc12

InChI Key InChIKey=ZIXQUQCWRLXDRC-UHFFFAOYSA-N

Data  8 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 26947   

TargetNociceptin receptor(Human)
Schering-Plough Research Institute

LigandPNGBDBM26947(CHEMBL239822 | 8-(4,4-dimethyl-1,2,3,4-tetrahydron...)
Affinity DataKi:  1.30nMAssay Description:IC50 values were obtained by fitting the competition binding curves according to a 4-parameter logistic model. Inhibition constants Ki were derived f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2009
Entry Details Article
PubMed
TargetNociceptin receptor(Human)
Schering-Plough Research Institute

LigandPNGBDBM26947(CHEMBL239822 | 8-(4,4-dimethyl-1,2,3,4-tetrahydron...)
Affinity DataKi:  1.30nMAssay Description:Displacement of [125I]nociceptin from human nociceptin receptor expressed in CHO cell membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
Schering-Plough Research Institute

LigandPNGBDBM26947(CHEMBL239822 | 8-(4,4-dimethyl-1,2,3,4-tetrahydron...)
Affinity DataKi:  48nMAssay Description:IC50 values were obtained by fitting the competition binding curves according to a 4-parameter logistic model. Inhibition constants Ki were derived f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2009
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
Schering-Plough Research Institute

LigandPNGBDBM26947(CHEMBL239822 | 8-(4,4-dimethyl-1,2,3,4-tetrahydron...)
Affinity DataKi:  48nMAssay Description:Displacement of [3H]diprenorphine from human mu opioid receptor expressed in CHO cell membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Schering-Plough Research Institute

LigandPNGBDBM26947(CHEMBL239822 | 8-(4,4-dimethyl-1,2,3,4-tetrahydron...)
Affinity DataKi:  540nMAssay Description:IC50 values were obtained by fitting the competition binding curves according to a 4-parameter logistic model. Inhibition constants Ki were derived f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2009
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Schering-Plough Research Institute

LigandPNGBDBM26947(CHEMBL239822 | 8-(4,4-dimethyl-1,2,3,4-tetrahydron...)
Affinity DataKi:  540nMAssay Description:Displacement of [3H]diprenorphine from human kappa opioid receptor expressed in CHO cell membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Human)
Schering-Plough Research Institute

LigandPNGBDBM26947(CHEMBL239822 | 8-(4,4-dimethyl-1,2,3,4-tetrahydron...)
Affinity DataKi:  1.79E+3nMAssay Description:IC50 values were obtained by fitting the competition binding curves according to a 4-parameter logistic model. Inhibition constants Ki were derived f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2009
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Human)
Schering-Plough Research Institute

LigandPNGBDBM26947(CHEMBL239822 | 8-(4,4-dimethyl-1,2,3,4-tetrahydron...)
Affinity DataKi:  1.79E+3nMAssay Description:Displacement of [3H]diprenorphine from human delta opioid receptor expressed in CHO cell membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed