BDBM26944 8-(4,4-dimethyl-1,2,3,4-tetrahydronaphthalen-1-yl)-1-phenyl-3-[2-(pyrrolidin-1-yl)ethyl]-1,3,8-triazaspiro[4.5]decan-4-one::spiropiperidine analogue, 65

SMILES CC1(C)CCC(N2CCC3(CC2)N(CN(CCN2CCCC2)C3=O)c2ccccc2)c2ccccc12

InChI Key InChIKey=VOSNJKFVBDSLTN-UHFFFAOYSA-N

Data  4 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 26944   

TargetNociceptin receptor(Human)
Schering-Plough Research Institute

LigandPNGBDBM26944(8-(4,4-dimethyl-1,2,3,4-tetrahydronaphthalen-1-yl)...)
Affinity DataKi:  1.40nMAssay Description:IC50 values were obtained by fitting the competition binding curves according to a 4-parameter logistic model. Inhibition constants Ki were derived f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2009
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
Schering-Plough Research Institute

LigandPNGBDBM26944(8-(4,4-dimethyl-1,2,3,4-tetrahydronaphthalen-1-yl)...)
Affinity DataKi:  69nMAssay Description:IC50 values were obtained by fitting the competition binding curves according to a 4-parameter logistic model. Inhibition constants Ki were derived f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2009
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Schering-Plough Research Institute

LigandPNGBDBM26944(8-(4,4-dimethyl-1,2,3,4-tetrahydronaphthalen-1-yl)...)
Affinity DataKi:  169nMAssay Description:IC50 values were obtained by fitting the competition binding curves according to a 4-parameter logistic model. Inhibition constants Ki were derived f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2009
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Human)
Schering-Plough Research Institute

LigandPNGBDBM26944(8-(4,4-dimethyl-1,2,3,4-tetrahydronaphthalen-1-yl)...)
Affinity DataKi:  1.22E+3nMAssay Description:IC50 values were obtained by fitting the competition binding curves according to a 4-parameter logistic model. Inhibition constants Ki were derived f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2009
Entry Details Article
PubMed