BDBM269435 (E)-3-(4-((2-(3-fluoro- 2- (trifluoromethyl) phenyl)-6- hydroxybenzo[b] thiophen-3- yl)oxy)phenyl)acrylic acid::US10058534, 90

SMILES OC(=O)\C=C\c1ccc(Oc2c(sc3cc(O)ccc23)-c2cccc(F)c2C(F)(F)F)cc1

InChI Key InChIKey=GCMDOOFJJQKWQF-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 269435   

TargetEstrogen receptor(Human)
Novartis

US Patent
LigandPNGBDBM269435((E)-3-(4-((2-(3-fluoro- 2- (trifluoromethyl) pheny...)
Affinity DataIC50: 26nMpH: 5.1 T: 2°CAssay Description:The ER transcription assay is a reporter assay that is based on the ability of ER to induce transcription from a luciferase reporter gene containing ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2018
Entry Details
Go to US Patent

TargetEstrogen receptor(Human)
Novartis

US Patent
LigandPNGBDBM269435((E)-3-(4-((2-(3-fluoro- 2- (trifluoromethyl) pheny...)
Affinity DataIC50: 1.20nMpH: 7.4 T: 2°CAssay Description:Plate MCF7 cells at 0.3 million cells/mL (100 l/well) in black, clear-bottom 96-well plates (Greiner, catalog number 655090) in DMEM/F12 media (Gibco...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2018
Entry Details
Go to US Patent