BDBM269409 (E)-3-(4-((6-hydroxy-2- (4-hydroxyphenyl)- benzo[b]thiophen-3- yl)oxy)phenyl)acrylamide::US10058534, 64

SMILES NC(=O)\C=C\c1ccc(Oc2c(sc3cc(O)ccc23)-c2ccc(O)cc2)cc1

InChI Key InChIKey=VSTANNMHRYLYHJ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 269409   

TargetEstrogen receptor(Human)
Novartis

US Patent
LigandPNGBDBM269409((E)-3-(4-((6-hydroxy-2- (4-hydroxyphenyl)- benzo[b...)
Affinity DataIC50: 40nMpH: 5.1 T: 2°CAssay Description:The ER transcription assay is a reporter assay that is based on the ability of ER to induce transcription from a luciferase reporter gene containing ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2018
Entry Details
Go to US Patent

TargetEstrogen receptor(Human)
Novartis

US Patent
LigandPNGBDBM269409((E)-3-(4-((6-hydroxy-2- (4-hydroxyphenyl)- benzo[b...)
Affinity DataIC50: 40nMAssay Description:Induction of selective estrogen receptor alpha degradation in human MCF7 cells harboring TK-ERE-Luc assessed as reduction in estradiol-induced transc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/25/2019
Entry Details Article
PubMed