BDBM269329 (R)-2-(3-fluoro-4'-(1-methyl-1H-pyrazol-4-yl)-[1,1'-biphenyl]-4-yl)-4,4-dimethyl-1-((1-(1-methylcyclopropanecarbonyl)pyrrolidin-3-yl)methyl)-1H-imidazol-5(4H)-one ::US10413545, Compound 74::US9718813, Compound 74

SMILES Cn1cc(cn1)-c1ccc(cc1)-c1ccc(C2=NC(C)(C)C(=O)N2C[C@@H]2CCN(C2)C(=O)C2(C)CC2)c(F)c1

InChI Key InChIKey=VATUMQCOXVLEAV-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 269329   

TargetFatty acid synthase(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM269329((R)-2-(3-fluoro-4'-(1-methyl-1H-pyrazol-4-yl)-[1,1...)
Affinity DataIC50: 55nMpH: 7.5 T: 2°CAssay Description:In this assay, inhibition of FASN activity is measured using 3H-acetyl-CoA and malonyl-CoA as substrates. 3H-Acetyl CoA is converted to 3H-palmitate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2018
Entry Details
Go to US Patent

Target1,5-anhydro-D-fructose reductase(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM269329((R)-2-(3-fluoro-4'-(1-methyl-1H-pyrazol-4-yl)-[1,1...)
Affinity DataIC50: 41.7nMpH: 7.5 T: 2°CAssay Description:10 μL assay buffer (100 mM KH2PO4 pH 7.5) was added to a 384-well clear plate (costar 3702). 0.3 μL compound (at concentrations of 30 μ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2018
Entry Details
Go to US Patent

TargetFatty acid synthase(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM269329((R)-2-(3-fluoro-4'-(1-methyl-1H-pyrazol-4-yl)-[1,1...)
Affinity DataIC50: 55nMAssay Description:In this assay, inhibition of FASN activity is measured using 3H-acetyl-CoA and malonyl-CoA as substrates. 3H-Acetyl CoA is converted to 3H-palmitate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2020
Entry Details
Go to US Patent