BDBM268516 N-(6-cyclopropyl-7-((3,4-dichlorophenoxy)methyl)-[1,2,4]-triazolo[4,3-a]pyridin-3-yl)methanesulfonamide::US9550775, 40::US9550775, 95

SMILES CS(=O)(=O)Nc1nnc2cc(COc3ccc(Cl)c(Cl)c3)c(cn12)C1CC1

InChI Key InChIKey=XLCJRUIKGPCZSQ-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 268516   

TargetSodium channel protein type 9 subunit alpha(Human)
Genentech

US Patent
LigandPNGBDBM268516(N-(6-cyclopropyl-7-((3,4-dichlorophenoxy)methyl)-[...)
Affinity DataIC50: 7.54nMpH: 7.2Assay Description:The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2018
Entry Details
Go to US Patent

TargetSodium channel protein type 9 subunit alpha(Human)
Genentech

US Patent
LigandPNGBDBM268516(N-(6-cyclopropyl-7-((3,4-dichlorophenoxy)methyl)-[...)
Affinity DataIC50: 8nMpH: 7.2Assay Description:The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2018
Entry Details
Go to US Patent

TargetSodium channel protein type 9 subunit alpha(Human)
Genentech

US Patent
LigandPNGBDBM268516(N-(6-cyclopropyl-7-((3,4-dichlorophenoxy)methyl)-[...)
Affinity DataIC50: 30nMAssay Description:Displacement of [3H]GX-545 from recombinant human NaV1.7 expressed in HEK293 cell membranes coexpressing Nav beta1 subunit after 18 hrs by liquid sci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed