BDBM268450 (3S,4R)-1-[3-(2-chloro-6- cyclopropyl- benzoyl)imidazo[1,5-a]pyridin-1- yl]-3-hydroxy-piperidine-4- carboxylic acid (RACEMATE)::US9550771, Example 49::US9550771, Example 51

SMILES O[C@@H]1CN(CC[C@H]1C(O)=O)c1nc(C(=O)c2c(Cl)cccc2C2CC2)n2ccccc12

InChI Key InChIKey=HEHJXQDTIPZDHS-UHFFFAOYSA-N

Data  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 268450   

TargetNuclear receptor ROR-gamma [262-507](Human)
Genentech

US Patent
LigandPNGBDBM268450(US9550771, Example 49 | (3S,4R)-1-[3-(2-chloro-6- ...)
Affinity DataEC50:  63nMT: 2°CAssay Description:ssays were carried out in 16-μL reaction volumes in black 384 Plus F Proxiplates (Perkin-Elmer 6008269). All assay components except test ligand...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2018
Entry Details
Go to US Patent

TargetNuclear receptor ROR-gamma [262-507](Human)
Genentech

US Patent
LigandPNGBDBM268450(US9550771, Example 49 | (3S,4R)-1-[3-(2-chloro-6- ...)
Affinity DataEC50:  29nMT: 2°CAssay Description:ssays were carried out in 16-μL reaction volumes in black 384 Plus F Proxiplates (Perkin-Elmer 6008269). All assay components except test ligand...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2018
Entry Details
Go to US Patent