BDBM267873 4-(8-amino-3-{(3R)-1-[(3-methyloxetan-3-yl)carbonyl]piperidin-3-yl}imidazo[1,5-a]pyrazin-1-yl)-N-(4-chloropyridin-2-yl)-3-fluorobenzamide::US9718828, Example, 486

SMILES CC(=O)N1CCC[C@H](C1)c1nc(-c2ccc(cc2F)C(=O)Nc2cc(ccn2)C(F)(F)F)c2c(N)nccn12

InChI Key InChIKey=VKXBHTAWXSYHEP-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 267873   

TargetTyrosine-protein kinase BTK(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM267873(4-(8-amino-3-{(3R)-1-[(3-methyloxetan-3-yl)carbony...)
Affinity DataIC50: 10nMAssay Description:BTK enzymatic activity was determined with the LANCE (Lanthanide Chelate Excite) TR-FRET (Time-resolved fluorescence resonance energy transfer) assay...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2018
Entry Details
Go to US Patent

TargetTyrosine-protein kinase BTK(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM267873(4-(8-amino-3-{(3R)-1-[(3-methyloxetan-3-yl)carbony...)
Affinity DataIC50: 11nMAssay Description:Inhibition of BTK in human PBMC assessed as reduction in anti-IgM-induced MIP1betaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/15/2020
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM267873(4-(8-amino-3-{(3R)-1-[(3-methyloxetan-3-yl)carbony...)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of recombinant full-length His6-tagged BTK (unknown origin) expressed in baculovirus infected Sf9 cells using biotinylated A5 peptide as s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/15/2020
Entry Details Article
PubMed
LigandPNGBDBM267873(4-(8-amino-3-{(3R)-1-[(3-methyloxetan-3-yl)carbony...)
Affinity DataIC50: 2.40E+3nMAssay Description:Inhibition of human ERG by [35S]-MK499 displacement or iKr channel assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/15/2020
Entry Details Article
PubMed