BDBM26784 3-(1,1-dioxo-1,2-thiazinan-2-yl)-5-(ethylamino)-N-[(2S,3R)-3-hydroxy-4-{[(3-methoxyphenyl)methyl]amino}-1-(1H-pyrazol-1-yl)butan-2-yl]benzamide::hydroxy ethylamine (HEA), 19

SMILES CCNc1cc(cc(c1)C(=O)N[C@@H](Cn1cccn1)[C@H](O)CNCc1cccc(OC)c1)N1CCCCS1(=O)=O

InChI Key InChIKey=OFELJLDMFBJYRB-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 26784   

TargetBeta-secretase 1(Human)
Gsk

LigandPNGBDBM26784(3-(1,1-dioxo-1,2-thiazinan-2-yl)-5-(ethylamino)-N-...)
Affinity DataIC50: 2.69E+3nMpH: 4.5 T: 2°CAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2009
Entry Details Article
PubMed
TargetBeta-secretase 2(Human)
Gsk

LigandPNGBDBM26784(3-(1,1-dioxo-1,2-thiazinan-2-yl)-5-(ethylamino)-N-...)
Affinity DataIC50: 1.00E+5nMAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2009
Entry Details Article
PubMed
TargetCathepsin D(Human)
Gsk

LigandPNGBDBM26784(3-(1,1-dioxo-1,2-thiazinan-2-yl)-5-(ethylamino)-N-...)
Affinity DataIC50: 1.00E+5nMAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2009
Entry Details Article
PubMed