BDBM267479 4-(8-amino-3-((trans)-4-hydroxycyclohexyl)imidazo[1,5-a]pyrazin-1-yl)-N-(4,5,6,7-tetrahydrobenzo[d]thiazol-2-yl)benzamide::US9718828, Example, 9

SMILES COc1cc(ccc1C(=O)Nc1ccccn1)-c1nc([C@H]2CC[C@H](O)CC2)n2ccnc(N)c12

InChI Key InChIKey=KZFQCCGYALYEKM-UHFFFAOYSA-N

Data  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 267479   

TargetTyrosine-protein kinase BTK(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM267479(4-(8-amino-3-((trans)-4-hydroxycyclohexyl)imidazo[...)
Affinity DataEC50:  55nMpH: 7.2 T: 2°CAssay Description:Btk enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below. Btk enzyme (...More data for this Ligand-Target Pair
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Date in BDB:
11/29/2018
Entry Details
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