BDBM267210 2-chloro-N-[2-(3,3-difluoroazetidin-1-yl)-2-(4-methyl-1,3-thiazol-5-yl)ethyl]-5-(5-fluoropyrimidin-2-yl)benzamide::US10167281, Compound 65::US9718812, 65

SMILES Cc1ncsc1C(CNC(=O)c1cc(ccc1Cl)-c1ncc(F)cn1)N1CC(F)(F)C1

InChI Key InChIKey=DOZGVHRCRSEOLO-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 267210   

TargetP2X purinoceptor 7(Human)
Axxam

US Patent
LigandPNGBDBM267210(2-chloro-N-[2-(3,3-difluoroazetidin-1-yl)-2-(4-met...)
Affinity DataIC50: 39nMAssay Description:Extracellular binding of Bz-ATP to P2X7 receptor opens the channel and allows Ca2+ influx into the cells. This Ca2+ entry was measured in HEK-293 cel...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2018
Entry Details
Go to US Patent

TargetP2X purinoceptor 7(Human)
Axxam

US Patent
LigandPNGBDBM267210(2-chloro-N-[2-(3,3-difluoroazetidin-1-yl)-2-(4-met...)
Affinity DataIC50: 39nMAssay Description:Extracellular binding of Bz-ATP to P2X7 receptor opens the channel and allows Ca2+ influx into the cells. This Ca2+ entry was measured in HEK-293 cel...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
Go to US Patent