BDBM267156 N-{2-[2-(2,4-difluorophenyl)morpholin-4-yl]-2-(4-methyl-1,3-thiazol-5-yl)ethyl}quinoline-5-carboxamide::US10167281, Compound 99::US9718812, 99

SMILES Cc1ncsc1C(CNC(=O)c1cccc2ncccc12)N1CCOC(C1)c1ccc(F)cc1F

InChI Key InChIKey=YVMKKVQJAADJDE-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 267156   

TargetP2X purinoceptor 7(Human)
Axxam

US Patent
LigandPNGBDBM267156(N-{2-[2-(2,4-difluorophenyl)morpholin-4-yl]-2-(4-m...)
Affinity DataIC50: 32nMAssay Description:Extracellular binding of Bz-ATP to P2X7 receptor opens the channel and allows Ca2+ influx into the cells. This Ca2+ entry was measured in HEK-293 cel...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2018
Entry Details
Go to US Patent

TargetP2X purinoceptor 7(Human)
Axxam

US Patent
LigandPNGBDBM267156(N-{2-[2-(2,4-difluorophenyl)morpholin-4-yl]-2-(4-m...)
Affinity DataIC50: 79nMAssay Description:YO-PRO -1 is a fluorescent DNA-binding dye with a MW of 374 Da (Molecular Probes, cat. Y3603). This method is based upon the presumed ability of YO-P...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2018
Entry Details
Go to US Patent

TargetP2X purinoceptor 7(Human)
Axxam

US Patent
LigandPNGBDBM267156(N-{2-[2-(2,4-difluorophenyl)morpholin-4-yl]-2-(4-m...)
Affinity DataIC50: 32nMAssay Description:Extracellular binding of Bz-ATP to P2X7 receptor opens the channel and allows Ca2+ influx into the cells. This Ca2+ entry was measured in HEK-293 cel...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
Go to US Patent

TargetP2X purinoceptor 7(Human)
Axxam

US Patent
LigandPNGBDBM267156(N-{2-[2-(2,4-difluorophenyl)morpholin-4-yl]-2-(4-m...)
Affinity DataIC50: 79nMAssay Description:YO-PRO -1 is a fluorescent DNA-binding dye with a MW of 374 Da (Molecular Probes, cat. Y3603). This method is based upon the presumed ability of YO-P...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
Go to US Patent