BDBM267139 N-{2-[4-(benzyloxy)piperidin-1-yl]-2-(1,3-thiazol-5-yl)ethyl}-2-chloro-6-methylbenzamide::US10167281, Compound 24::US9718812, 24

SMILES Cc1cccc(Cl)c1C(=O)NCC(N1CCC(CC1)OCc1ccccc1)c1cncs1

InChI Key InChIKey=GLCZBQMBGCOXQU-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 267139   

TargetP2X purinoceptor 7(Human)
Axxam

US Patent
LigandPNGBDBM267139(N-{2-[4-(benzyloxy)piperidin-1-yl]-2-(1,3-thiazol-...)
Affinity DataIC50: 111nMAssay Description:Extracellular binding of Bz-ATP to P2X7 receptor opens the channel and allows Ca2+ influx into the cells. This Ca2+ entry was measured in HEK-293 cel...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2018
Entry Details
Go to US Patent

TargetP2X purinoceptor 7(Human)
Axxam

US Patent
LigandPNGBDBM267139(N-{2-[4-(benzyloxy)piperidin-1-yl]-2-(1,3-thiazol-...)
Affinity DataIC50: 44nMAssay Description:YO-PRO -1 is a fluorescent DNA-binding dye with a MW of 374 Da (Molecular Probes, cat. Y3603). This method is based upon the presumed ability of YO-P...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2018
Entry Details
Go to US Patent

TargetP2X purinoceptor 7(Human)
Axxam

US Patent
LigandPNGBDBM267139(N-{2-[4-(benzyloxy)piperidin-1-yl]-2-(1,3-thiazol-...)
Affinity DataIC50: 111nMAssay Description:Extracellular binding of Bz-ATP to P2X7 receptor opens the channel and allows Ca2+ influx into the cells. This Ca2+ entry was measured in HEK-293 cel...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
Go to US Patent

TargetP2X purinoceptor 7(Human)
Axxam

US Patent
LigandPNGBDBM267139(N-{2-[4-(benzyloxy)piperidin-1-yl]-2-(1,3-thiazol-...)
Affinity DataIC50: 44nMAssay Description:YO-PRO -1 is a fluorescent DNA-binding dye with a MW of 374 Da (Molecular Probes, cat. Y3603). This method is based upon the presumed ability of YO-P...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
Go to US Patent