BDBM26660 3,7-dihydroxy-2-phenyl-4H-chromen-4-one::3,7-dihydroxyflavone::CHEMBL210276

SMILES c1ccc(cc1)C2=C(C(=O)c3ccc(cc3O2)O)O

InChI Key InChIKey=UWQJWDYDYIJWKY-UHFFFAOYSA-N

Data  10 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 26660   

TargetSerine/threonine-protein kinase pim-1(Human)
Loma Linda University

LigandPNGBDBM26660(3,7-dihydroxy-2-phenyl-4H-chromen-4-one | CHEMBL21...)
Affinity DataIC50: 4.60E+3nMpH: 7.0 T: 2°CAssay Description:The 96-well flat-bottomed plates were coated with recombinant GST-BAD. After the plates were blocked, the reaction buffer containing test compound an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2009
Entry Details Article
PubMed
TargetDipeptidyl peptidase 3(Human)
Josip Juraj Strossmayer University of Osijek

LigandPNGBDBM26660(3,7-dihydroxy-2-phenyl-4H-chromen-4-one | CHEMBL21...)
Affinity DataIC50: 9.80E+4nMpH: 7.4 T: 2°CAssay Description:The inhibitory activity of flavonoids toward human DPP III was assayed in a 50 mM Tris-HCl buffer, pH 7.4. In brief, recombinant human DPP III (0.29 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/26/2017
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase pim-1(Human)
Loma Linda University

LigandPNGBDBM26660(3,7-dihydroxy-2-phenyl-4H-chromen-4-one | CHEMBL21...)
Affinity DataIC50: 4.57E+3nMAssay Description:Inhibition of PIM1 kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15B(Human)
Universidad De Santiago De Chile

Curated by ChEMBL
LigandPNGBDBM26660(3,7-dihydroxy-2-phenyl-4H-chromen-4-one | CHEMBL21...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of 15-hLO2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Human)
Universidad De Santiago De Chile

Curated by ChEMBL
LigandPNGBDBM26660(3,7-dihydroxy-2-phenyl-4H-chromen-4-one | CHEMBL21...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of 15-hLO1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX12(Human)
Universidad De Santiago De Chile

Curated by ChEMBL
LigandPNGBDBM26660(3,7-dihydroxy-2-phenyl-4H-chromen-4-one | CHEMBL21...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of 12-hLOMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProlyl endopeptidase(Human)
Institut De Recerca BiomèDica De Barcelona

Curated by ChEMBL
LigandPNGBDBM26660(3,7-dihydroxy-2-phenyl-4H-chromen-4-one | CHEMBL21...)
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of human brain prolyl oligopeptidase expressed in Escherichia coliMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetDipeptidyl peptidase 4(Human)
Institut De Recerca BiomèDica De Barcelona

Curated by ChEMBL
LigandPNGBDBM26660(3,7-dihydroxy-2-phenyl-4H-chromen-4-one | CHEMBL21...)
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of DPP4More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetEnoyl-acyl-carrier protein reductase(malaria parasite P. falciparum)
University of Zurich

Curated by ChEMBL
LigandPNGBDBM26660(3,7-dihydroxy-2-phenyl-4H-chromen-4-one | CHEMBL21...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of FabIMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2012
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Central University of Punjab

Curated by ChEMBL
LigandPNGBDBM26660(3,7-dihydroxy-2-phenyl-4H-chromen-4-one | CHEMBL21...)
Affinity DataIC50: 1.25E+7nMAssay Description:Inhibition of P-gp in human HK2 cells assessed as Rhodamine-123 accumulation by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed