BDBM26659 7,3-dihydroxyflavone::7-hydroxy-2-(3-hydroxyphenyl)-4H-chromen-4-one

SMILES c1cc(cc(c1)O)C2=CC(=O)c3ccc(cc3O2)O

InChI Key InChIKey=DYARIVMCYYQNNQ-UHFFFAOYSA-N

Data  6 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 26659   

TargetSerine/threonine-protein kinase pim-1(Human)
Loma Linda University

LigandPNGBDBM26659(7-hydroxy-2-(3-hydroxyphenyl)-4H-chromen-4-one | 7...)
Affinity DataIC50: 4.52E+3nMpH: 7.0 T: 2°CAssay Description:The 96-well flat-bottomed plates were coated with recombinant GST-BAD. After the plates were blocked, the reaction buffer containing test compound an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase pim-1(Human)
Loma Linda University

LigandPNGBDBM26659(7-hydroxy-2-(3-hydroxyphenyl)-4H-chromen-4-one | 7...)
Affinity DataIC50: 4.57E+3nMAssay Description:Inhibition of PIM1 kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM26659(7-hydroxy-2-(3-hydroxyphenyl)-4H-chromen-4-one | 7...)
Affinity DataIC50: 3.93E+4nMAssay Description:Inhibition of p56 lckMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2010
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
University of Oulu

Curated by ChEMBL
LigandPNGBDBM26659(7-hydroxy-2-(3-hydroxyphenyl)-4H-chromen-4-one | 7...)
Affinity DataIC50: 9.50E+3nMAssay Description:Inhibition of human recombinant ARTD1 by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase tankyrase-2(Human)
University of Oulu

Curated by ChEMBL
LigandPNGBDBM26659(7-hydroxy-2-(3-hydroxyphenyl)-4H-chromen-4-one | 7...)
Affinity DataIC50: 620nMAssay Description:Inhibition of human 6XHis-tagged TNKS2 ART domain (946 to 1161 amino acid residues) expressed in Escherichia coli Rosetta2 (DE3) by fluorescence assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase tankyrase-1(Human)
University of Oulu

Curated by ChEMBL
LigandPNGBDBM26659(7-hydroxy-2-(3-hydroxyphenyl)-4H-chromen-4-one | 7...)
Affinity DataIC50: 280nMAssay Description:Inhibition of human 6XHis-tagged TNKS1 SAM-ART domain (1030 to 1317 amino acid residues) by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed