BDBM26640 (5Z)-5-[(4-fluorophenyl)methylidene]-1,3-thiazolidine-2,4-dione::thiazolidine-2,4-dione, 18a

SMILES OC1=NC(=O)C(S1)=Cc1ccc(F)cc1

InChI Key InChIKey=XQEXVSOHLCLCFH-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 26640   

TargetSerine/threonine-protein kinase pim-1(Human)
Medical University of South Carolina

LigandPNGBDBM26640((5Z)-5-[(4-fluorophenyl)methylidene]-1,3-thiazolid...)
Affinity DataIC50: 13nMpH: 7.0 T: 2°CAssay Description:The primary screen and evaluation of the compounds was conducted using an ATP-depletion assay. Recombinant human Pim kinase was incubated with S6 kin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase pim-2(Human)
Medical University of South Carolina

LigandPNGBDBM26640((5Z)-5-[(4-fluorophenyl)methylidene]-1,3-thiazolid...)
Affinity DataIC50: 2.30E+3nMAssay Description:The primary screen and evaluation of the compounds was conducted using an ATP-depletion assay. Recombinant human Pim kinase was incubated with S6 kin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2009
Entry Details Article
PubMed
TargetTyrosyl-DNA phosphodiesterase 1(Human)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM26640((5Z)-5-[(4-fluorophenyl)methylidene]-1,3-thiazolid...)
Affinity DataIC50: 3.33E+5nMAssay Description:Inhibition of human recombinant Tdp1 assessed as conversion of 14-mer 5'-32P-labeled 3'-phosphotyrosyl DNA substrate N14Y to 14-mer 5'-32P-labeled 3'...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed