BDBM26623 (5Z)-5-[(4-methylphenyl)methylidene]-1,3-thiazolidine-2,4-dione::US8637558, 41::thiazolidine-2,4-dione, 1a

SMILES Cc1ccc(C=C2SC(O)=NC2=O)cc1

InChI Key InChIKey=VUXDSWRSGDQYRJ-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 26623   

TargetSerine/threonine-protein kinase pim-1(Human)
Medical University of South Carolina

LigandPNGBDBM26623(US8637558, 41 | (5Z)-5-[(4-methylphenyl)methyliden...)
Affinity DataIC50: 60nMpH: 7.0 T: 2°CAssay Description:The primary screen and evaluation of the compounds was conducted using an ATP-depletion assay. Recombinant human Pim kinase was incubated with S6 kin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase pim-2(Human)
Medical University of South Carolina

LigandPNGBDBM26623(US8637558, 41 | (5Z)-5-[(4-methylphenyl)methyliden...)
Affinity DataIC50: 4.40E+3nMAssay Description:The primary screen and evaluation of the compounds was conducted using an ATP-depletion assay. Recombinant human Pim kinase was incubated with S6 kin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2009
Entry Details Article
PubMed
Target15-hydroxyprostaglandin dehydrogenase [NAD(+)](Human)
Industry-Academic Cooperation Foundation, Chosun University

US Patent
LigandPNGBDBM26623(US8637558, 41 | (5Z)-5-[(4-methylphenyl)methyliden...)
Affinity DataIC50: 5.82E+3nMpH: 7.5Assay Description:Experimental was performed by measuring the formation of NADH at 340 nm with a fluorescence spectrophotometer. Specifically, 2 ml (in total) of the s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2014
Entry Details
Go to US Patent