BDBM26505 BMCL181022 Compound 12::N-[(2S,3R)-4-(benzylamino)-3-hydroxy-1-phenylbutan-2-yl]-3-(1,1-dioxo-1,2-thiazinan-2-yl)-5-(ethylamino)benzamide::sultam hydroxyethylamine (HEA) derivative, 9b

SMILES CCNc1cc(cc(c1)C(=O)N[C@@H](Cc1ccccc1)[C@H](O)CNCc1ccccc1)N1CCCCS1(=O)=O

InChI Key InChIKey=WUYOJSGIKRCAKP-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 26505   

TargetBeta-secretase 1(Human)
Gsk

LigandPNGBDBM26505(N-[(2S,3R)-4-(benzylamino)-3-hydroxy-1-phenylbutan...)
Affinity DataIC50: 120nMpH: 4.5 T: 2°CAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/24/2009
Entry Details Article
PubMed
TargetBeta-secretase 2(Human)
Gsk

LigandPNGBDBM26505(N-[(2S,3R)-4-(benzylamino)-3-hydroxy-1-phenylbutan...)
Affinity DataIC50: 3.24E+4nMpH: 4.5 T: 2°CAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/24/2009
Entry Details Article
PubMed
TargetCathepsin D(Human)
Gsk

LigandPNGBDBM26505(N-[(2S,3R)-4-(benzylamino)-3-hydroxy-1-phenylbutan...)
Affinity DataIC50: 2.63E+4nMAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/24/2009
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Gsk

LigandPNGBDBM26505(N-[(2S,3R)-4-(benzylamino)-3-hydroxy-1-phenylbutan...)
Affinity DataIC50: 120nMpH: 4.5 T: 2°CAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2009
Entry Details Article
PubMed
TargetBeta-secretase 2(Human)
Gsk

LigandPNGBDBM26505(N-[(2S,3R)-4-(benzylamino)-3-hydroxy-1-phenylbutan...)
Affinity DataIC50: 3.24E+4nMAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2009
Entry Details Article
PubMed
TargetCathepsin D(Human)
Gsk

LigandPNGBDBM26505(N-[(2S,3R)-4-(benzylamino)-3-hydroxy-1-phenylbutan...)
Affinity DataIC50: 2.63E+4nMAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2009
Entry Details Article
PubMed