BDBM264359 US9714247, 80

SMILES Fc1ccc(Nc2cc3n(C4CCOCC4)c(=O)c(cc3cn2)-c2c(F)cccc2F)nc1

InChI Key InChIKey=CZGRMMPDCOTQNK-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 264359   

TargetTyrosine-protein kinase BTK(Human)
Tolero Pharmaceuticals

US Patent
LigandPNGBDBM264359(US9714247, 80)
Affinity DataIC50: 550nMAssay Description:A concentration of a drug that reduces the observed activity of an enzyme by 50%. An IC50 is not a true affinity constant and the specific value dete...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2018
Entry Details
Go to US Patent

TargetProto-oncogene tyrosine-protein kinase Src(Human)
Tolero Pharmaceuticals

US Patent
LigandPNGBDBM264359(US9714247, 80)
Affinity DataIC50: 5.00E+3nMAssay Description:A concentration of a drug that reduces the observed activity of an enzyme by 50%. An IC50 is not a true affinity constant and the specific value dete...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2018
Entry Details
Go to US Patent

TargetTyrosine-protein kinase Lyn(Human)
Tolero Pharmaceuticals

US Patent
LigandPNGBDBM264359(US9714247, 80)
Affinity DataIC50: 100nMAssay Description:A concentration of a drug that reduces the observed activity of an enzyme by 50%. An IC50 is not a true affinity constant and the specific value dete...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2018
Entry Details
Go to US Patent