BDBM264130 3-(3-Bromo-2-methylphenyl)-8-fluoro-1-methyl(d3)quinazoline-2,4(1H,3H)-dione::US9714234, 5

SMILES Cc1c(Br)cccc1-n1c(=O)n(C)c2c(F)cccc2c1=O

InChI Key InChIKey=JXWGMQPPQLQVGP-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 264130   

TargetTyrosine-protein kinase BTK(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM264130(3-(3-Bromo-2-methylphenyl)-8-fluoro-1-methyl(d3)qu...)
Affinity DataIC50: 0.900nMpH: 7.4 T: 2°CAssay Description:To V-bottom 384-well plates were added test compounds, human recombinant Btk (1 nM, INVITROGEN Corporation), fluoresceinated peptide (1.5 μM), A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2018
Entry Details
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TargetTyrosine-protein kinase JAK2(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM264130(3-(3-Bromo-2-methylphenyl)-8-fluoro-1-methyl(d3)qu...)
Affinity DataIC50: 1.20E+3nMpH: 7.4 T: 2°CAssay Description:Compounds with activity against Jak2 tyrosine kinase have been observed to cause thrombocytopenia, anemia and neutropenia in human patients in clinic...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2018
Entry Details
Go to US Patent