BDBM264110 3-(2-(4-(4-(4-methoxy-2-oxopyridin-1(2H)-yl)phenyl)piperazin-1-yl)ethyl)-1H-indole-5-carbonitrile::US9714232, 23

SMILES COc1ccn(-c2ccc(cc2)N2CCN(CCc3c[nH]c4ccc(cc34)C#N)CC2)c(=O)c1

InChI Key InChIKey=YSPVXNSRCZUGOK-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 264110   

Target5-hydroxytryptamine receptor 1A(Rat)
Sunshine Lake Pharma

US Patent
LigandPNGBDBM264110(3-(2-(4-(4-(4-methoxy-2-oxopyridin-1(2H)-yl)phenyl...)
Affinity DataIC50: 12nMpH: 7.4Assay Description:The synaptosomes (150 μg) prepared from a rat brain were incubated at 37° C. for 15 minutes with 0.1 μCi [3H]5-HT in the absence or presenc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2018
Entry Details
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TargetSodium-dependent serotonin transporter(Rat)
Sunshine Lake Pharma

Curated by ChEMBL
LigandPNGBDBM264110(3-(2-(4-(4-(4-methoxy-2-oxopyridin-1(2H)-yl)phenyl...)
Affinity DataIC50: 12nMAssay Description:Inhibition of serotonin transporter expressed in rat brain tissue assessed as inhibition of [3H]-5-hydroxytryptamine reuptake measured after 15 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed