BDBM264104 3-(4-(4-(4-(4-methyl-2-oxopyridin-1(2H)-yl)phenyl)piperazin-1-yl)butyl)-1H-indole-5-carbonitrile::US9714232, 17

SMILES Cc1ccn(-c2ccc(cc2)N2CCN(CCCCc3c[nH]c4ccc(cc34)C#N)CC2)c(=O)c1

InChI Key InChIKey=HFYSALVEJKPMHH-UHFFFAOYSA-N

Data  1 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 264104   

Target5-hydroxytryptamine receptor 1A(Rat)
Sunshine Lake Pharma

US Patent
LigandPNGBDBM264104(3-(4-(4-(4-(4-methyl-2-oxopyridin-1(2H)-yl)phenyl)...)
Affinity DataIC50: 1.70nMpH: 7.4Assay Description:The synaptosomes (150 μg) prepared from a rat brain were incubated at 37° C. for 15 minutes with 0.1 μCi [3H]5-HT in the absence or presenc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2018
Entry Details
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TargetSodium-dependent serotonin transporter(Rat)
Sunshine Lake Pharma

Curated by ChEMBL
LigandPNGBDBM264104(3-(4-(4-(4-(4-methyl-2-oxopyridin-1(2H)-yl)phenyl)...)
Affinity DataIC50: 2nMAssay Description:Inhibition of serotonin transporter expressed in rat brain tissue assessed as inhibition of [3H]-5-hydroxytryptamine reuptake measured after 15 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Sunshine Lake Pharma

US Patent
LigandPNGBDBM264104(3-(4-(4-(4-(4-methyl-2-oxopyridin-1(2H)-yl)phenyl)...)
Affinity DataKi:  0.480nMpH: 7.4Assay Description:Human HEK-293 cell homogenates (36 μg protein) were incubated at 22° C. for 60 minutes with 0.3 nM [3H]8-0H-DPAT (Perkin-Elmer) in the absence o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2018
Entry Details
Go to US Patent