BDBM264030 2-[5-[(4-chloro-2- ethoxyphenyl)methoxy]pyrazol-1- yl]pyridine-4-carboxylic acid::US10173996, Example 115::US20240139197, Compound 35::US9604961, Example 115::US9714230, 115::US9908865, Example 115

SMILES CCOc1cc(Cl)ccc1COc1ccnn1-c1cc(ccn1)C(O)=O

InChI Key InChIKey=GTWJZXSSCNHGGN-UHFFFAOYSA-N

Data  9 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 264030   

TargetLysine-specific demethylase 5A(Human)
Celgene Quanticel Research

US Patent
LigandPNGBDBM264030(2-[5-[(4-chloro-2- ethoxyphenyl)methoxy]pyrazol-1-...)
Affinity DataIC50: 100nMAssay Description:The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/27/2020
Entry Details
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TargetLysine-specific demethylase 5B(Human)
Celgene Quanticel Research

US Patent
LigandPNGBDBM264030(2-[5-[(4-chloro-2- ethoxyphenyl)methoxy]pyrazol-1-...)
Affinity DataIC50: 100nMAssay Description:The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction conditions: 0.8...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/27/2020
Entry Details
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TargetLysine-specific demethylase 4C(Human)
Celgene Quanticel Research

US Patent
LigandPNGBDBM264030(2-[5-[(4-chloro-2- ethoxyphenyl)methoxy]pyrazol-1-...)
Affinity DataIC50: 550nMAssay Description:The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/27/2020
Entry Details
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TargetLysine-specific demethylase 5A/5B(Human)
Celgene

Curated by ChEMBL
LigandPNGBDBM264030(2-[5-[(4-chloro-2- ethoxyphenyl)methoxy]pyrazol-1-...)
Affinity DataEC50:  1.00E+3nMAssay Description:Inhibition of KDM5A/KDM5B in human ZR-75-1 cells assessed as increase in H3K4me3 level after 72 hrs by fluorometric immunoassayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetLysine-specific demethylase 4C(Human)
Celgene Quanticel Research

US Patent
LigandPNGBDBM264030(2-[5-[(4-chloro-2- ethoxyphenyl)methoxy]pyrazol-1-...)
Affinity DataIC50: 78nMAssay Description:Inhibition of KDM4C (unknown origin) preincubated with enzymeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetLysine-specific demethylase 5B(Human)
Celgene Quanticel Research

US Patent
LigandPNGBDBM264030(2-[5-[(4-chloro-2- ethoxyphenyl)methoxy]pyrazol-1-...)
Affinity DataIC50: 4nMAssay Description:Inhibition of KDM5B (unknown origin) preincubated with enzymeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetLysine-specific demethylase 5A(Human)
Celgene Quanticel Research

US Patent
LigandPNGBDBM264030(2-[5-[(4-chloro-2- ethoxyphenyl)methoxy]pyrazol-1-...)
Affinity DataIC50: 19nMAssay Description:Inhibition of KDM5A (unknown origin) preincubated with enzymeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetLysine-specific demethylase 5A(Human)
Celgene Quanticel Research

US Patent
LigandPNGBDBM264030(2-[5-[(4-chloro-2- ethoxyphenyl)methoxy]pyrazol-1-...)
Affinity DataIC50: 18nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2024
Entry Details
Go to US Patent

TargetLysine-specific demethylase 5B(Human)
Celgene Quanticel Research

US Patent
LigandPNGBDBM264030(2-[5-[(4-chloro-2- ethoxyphenyl)methoxy]pyrazol-1-...)
Affinity DataIC50: 4nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2024
Entry Details
Go to US Patent

TargetLysine-specific demethylase 4C(Human)
Celgene Quanticel Research

US Patent
LigandPNGBDBM264030(2-[5-[(4-chloro-2- ethoxyphenyl)methoxy]pyrazol-1-...)
Affinity DataIC50: 78nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2024
Entry Details
Go to US Patent