BDBM26395 2,4-diamino-5,6-disubstituted pyrimidine, 9::6-(piperazin-1-yl)-3,5-diazatricyclo[9.4.0.0^{2,7}]pentadeca-1(15),2(7),3,5,11,13-hexaen-4-amine

SMILES Nc1nc(N2CCNCC2)c2CCCc3ccccc3-c2n1

InChI Key InChIKey=KUZRWWLVBUPCRK-UHFFFAOYSA-N

Data  3 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 26395   

TargetHistamine H4 receptor(Rat)
Abbott Laboratories

LigandPNGBDBM26395(6-(piperazin-1-yl)-3,5-diazatricyclo[9.4.0.0^{2,7}...)
Affinity DataKi:  7.60nM ΔG°:  -11.1kcal/molepH: 7.4 T: 2°CAssay Description:Competition radioligand binding assays were performed with increasing concentrations of test compound in the presence of [3H]ligand. All binding reac...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2009
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
Abbott Laboratories

LigandPNGBDBM26395(6-(piperazin-1-yl)-3,5-diazatricyclo[9.4.0.0^{2,7}...)
Affinity DataKi:  71nM ΔG°:  -9.75kcal/molepH: 7.4 T: 2°CAssay Description:Competition radioligand binding assays were performed with increasing concentrations of test compound in the presence of [3H]ligand. All binding reac...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2009
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
Abbott Laboratories

LigandPNGBDBM26395(6-(piperazin-1-yl)-3,5-diazatricyclo[9.4.0.0^{2,7}...)
Affinity DataKi:  79.4nMAssay Description:Binding affinity to H4R receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed