BDBM263940 2-(5-hydroxy-3-(phenoxymethyl)- 1H-pyrazol-1-yl)isonicotinic acid::US10173996, Example 10::US9604961, Example 10::US9714230, 10::US9908865, Example 10

SMILES OC(=O)c1ccnc(c1)-n1nc(COc2ccccc2)cc1O

InChI Key InChIKey=JFEKVRDZSRWNEZ-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 263940   

TargetLysine-specific demethylase 5A(Human)
Celgene Quanticel Research

US Patent
LigandPNGBDBM263940(2-(5-hydroxy-3-(phenoxymethyl)- 1H-pyrazol-1-yl)is...)
Affinity DataIC50: 5.50E+3nMAssay Description:The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/27/2020
Entry Details
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TargetLysine-specific demethylase 5B(Human)
Celgene Quanticel Research

US Patent
LigandPNGBDBM263940(2-(5-hydroxy-3-(phenoxymethyl)- 1H-pyrazol-1-yl)is...)
Affinity DataIC50: 550nMAssay Description:The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction conditions: 0.8...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/27/2020
Entry Details
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TargetLysine-specific demethylase 4C(Human)
Celgene Quanticel Research

US Patent
LigandPNGBDBM263940(2-(5-hydroxy-3-(phenoxymethyl)- 1H-pyrazol-1-yl)is...)
Affinity DataIC50: 1.00E+4nMAssay Description:The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/27/2020
Entry Details
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TargetLysine-specific demethylase 2B(Human)
Celgene Quanticel Research

US Patent
LigandPNGBDBM263940(2-(5-hydroxy-3-(phenoxymethyl)- 1H-pyrazol-1-yl)is...)
Affinity DataIC50: 100nMAssay Description:The ability of test compounds to inhibit the activity of FBXL10 was determined in 384-well plate format under the following reaction conditions: 0.3 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/27/2020
Entry Details
Go to US Patent