BDBM263564 US9556150, i-52::[1-(2-{5-amino-1-[2-chloro-4- (2-dimethylcarbamoyl-phenoxy)- phenyl]-1hpyrazole-4-carbonyl}- 1h-indole-5-carbonyl)- pyrrolidin-3-yl]-methyl-carbamic acid tert-butyl ester

SMILES CN(C)C(=O)c1ccccc1Oc1ccc(c(Cl)c1)-n1ncc(C(=O)c2cc3cc(ccc3[nH]2)C(=O)N2CCC(C2)N(C)C(=O)OC(C)(C)C)c1N

InChI Key InChIKey=NDODNIYYGCXIGS-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 263564   

TargetTyrosine-protein kinase BTK(Human)
F. Hoffmann-La Roche

US Patent
LigandPNGBDBM263564([1-(2-{5-amino-1-[2-chloro-4- (2-dimethylcarbamoyl...)
Affinity DataIC50: 17nMpH: 7.15Assay Description:This BTK competition assay measures compound potency (IC50) for the inactivated state of Bruton's Tyrosine Kinase using FRET (F rster/Fluorescenc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2018
Entry Details
Go to US Patent