BDBM262604 4′-(piperidin-4-yl)-4-(piperidin-4-ylmethyl)-2-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-3-sulfonamide::US9708336, 456

SMILES NS(=O)(=O)c1c(CC2CCNCC2)ccc(-c2ccc(cc2)C2CCNCC2)c1-c1nn[nH]n1

InChI Key InChIKey=LHOHTNKBXFSQBC-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 262604   

TargetMetallo-beta-lactamase type 2(Serratia marcescens)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM262604(4′-(piperidin-4-yl)-4-(piperidin-4-ylmethyl)...)
Affinity DataIC50: 9.79nMpH: 7.0Assay Description:The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/5/2018
Entry Details
Go to US Patent

TargetMetallo-beta-lactamase type 2(Pseudomonas aeruginosa (g-Proteobacteria))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM262604(4′-(piperidin-4-yl)-4-(piperidin-4-ylmethyl)...)
Affinity DataIC50: 4.58nMpH: 7.0Assay Description:The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/5/2018
Entry Details
Go to US Patent

TargetVIM-1 metallo-beta-lactamase(Pseudomonas aeruginosa (g-Proteobacteria))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM262604(4′-(piperidin-4-yl)-4-(piperidin-4-ylmethyl)...)
Affinity DataIC50: 3.44nMpH: 7.0Assay Description:The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/5/2018
Entry Details
Go to US Patent

TargetSodium channel protein type 5 subunit alpha(Human)
Merck & Co.

Curated by ChEMBL
LigandPNGBDBM262604(4′-(piperidin-4-yl)-4-(piperidin-4-ylmethyl)...)
Affinity DataIC50: 3.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
LigandPNGBDBM262604(4′-(piperidin-4-yl)-4-(piperidin-4-ylmethyl)...)
Affinity DataIC50: 3.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
LigandPNGBDBM262604(4′-(piperidin-4-yl)-4-(piperidin-4-ylmethyl)...)
Affinity DataIC50: 3.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed