BDBM2623 1-methyl-3-[4-(1-methyl-1H-indol-3-yl)-2,5-dioxo-2,5-dihydro-1H-pyrrol-3-yl]-1H-indole-6-carboxylic acid::Bisindolylmaleimide deriv. 45::ROCHE screening, 44

SMILES Cn1cc(C2=C(C(=O)NC2=O)c2cn(C)c3cc(ccc23)C(O)=O)c2ccccc12

InChI Key InChIKey=BQVYRVFEBOGTBZ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 2623   

TargetProtein kinase C beta type(Rat)
Roche Products

LigandPNGBDBM2623(1-methyl-3-[4-(1-methyl-1H-indol-3-yl)-2,5-dioxo-2...)
Affinity DataIC50: 2.70E+4nMAssay Description:The activity of PKC, activated by phosphatidylerine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich his...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2004
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase TBK1(Human)
Technical University of Dortmund

LigandPNGBDBM2623(1-methyl-3-[4-(1-methyl-1H-indol-3-yl)-2,5-dioxo-2...)
Affinity DataIC50: 971nMAssay Description:IC50 determinations for TBK1 were performed with the KinEASE-STK assay from Cisbio according to the manufacturer's instructions. A biotinylated s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2015
Entry Details Article
PubMed