BDBM262131 6-Amino-9-[(4-chloro-3-fluorophenyl)methyl]-2-(propylsulfonimidoyl)-7H-purin-8-one::US11242345, Example 30::US9708325, 30

SMILES CCCS(=N)(=O)c1nc(N)c2[nH]c(=O)n(Cc3ccc(Cl)c(F)c3)c2n1

InChI Key InChIKey=RXVPTJHAOBJTOO-UHFFFAOYSA-N

Data  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 262131   

TargetToll-like receptor 7(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM262131(6-Amino-9-[(4-chloro-3-fluorophenyl)methyl]-2-(pro...)
Affinity DataEC50:  18nMAssay Description:HEK-Blue-hTLR7 cells were incubated at a density of 250,000˜450,000 cells/mL in a volume of 180 μL in a 96-well plate in Dulbecco's Mod...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2018
Entry Details
Go to US Patent

TargetToll-like receptor 7(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM262131(6-Amino-9-[(4-chloro-3-fluorophenyl)methyl]-2-(pro...)
Affinity DataEC50:  18nMAssay Description:A stable HEK-Blue-hTLR7 cell line was purchased from InvivoGen (Cat. #: hkb-htlr7, San Diego, Calif., USA). These cells were designed for studying th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2022
Entry Details
Go to US Patent