BDBM26199 N-[4-(4-methylpiperazin-1-yl)phenyl]-3-phenyl-1H-pyrazolo[4,3-d]pyrimidin-5-amine::pyrazolopyrimidine, 3

SMILES CN1CCN(CC1)c1ccc(Nc2ncc3[nH]nc(-c4ccccc4)c3n2)cc1

InChI Key InChIKey=HPOZHFRJHZDSHY-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 26199   

TargetTyrosine-protein kinase JAK3(Human)
Johnson & Johnson Pharmaceutical

LigandPNGBDBM26199(N-[4-(4-methylpiperazin-1-yl)phenyl]-3-phenyl-1H-p...)
Affinity DataIC50: 98nMpH: 7.5 T: 2°CAssay Description:An ELISA assay was used to determine the ability of inhibitor to inhibit JAK3 RTK activity. The compounds were incubated with enzyme, 10 uM ATP, and ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2008
Entry Details Article
PubMed