BDBM261978 1-(4-(1H-pyrazol-1-yl)phenyl)- 3-(2,6-difluoro-3,5- dimethoxyphenyl)-7-(1,3- dimethyl-1H-pyrazol-4-yl)-3,4- dihydropyrido[4,3-d]pyrimidin- 2(1H)-one::US10251892, Example 77::US10632126, Example 77::US11173162, Example 77::US9708318, 77

SMILES COc1cc(OC)c(F)c(N2Cc3cnc(cc3N(C2=O)c2ccc(cc2)-n2cccn2)-c2cn(C)nc2C)c1F

InChI Key InChIKey=WRPGQHQMZGBISW-UHFFFAOYSA-N

Data  16 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 16 hits for monomerid = 261978   

TargetFibroblast growth factor receptor 2(Human)
Incyte

US Patent
LigandPNGBDBM261978(1-(4-(1H-pyrazol-1-yl)phenyl)- 3-(2,6-difluoro-3,5...)
Affinity DataIC50: 10nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/10/2021
Entry Details
US Patent

TargetFibroblast growth factor receptor 3(Human)
Incyte

US Patent
LigandPNGBDBM261978(1-(4-(1H-pyrazol-1-yl)phenyl)- 3-(2,6-difluoro-3,5...)
Affinity DataIC50: 10nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/10/2021
Entry Details
US Patent

TargetFibroblast growth factor receptor 2(Human)
Incyte

US Patent
LigandPNGBDBM261978(1-(4-(1H-pyrazol-1-yl)phenyl)- 3-(2,6-difluoro-3,5...)
Affinity DataIC50: 10nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2022
Entry Details
US Patent

TargetFibroblast growth factor receptor 3(Human)
Incyte

US Patent
LigandPNGBDBM261978(1-(4-(1H-pyrazol-1-yl)phenyl)- 3-(2,6-difluoro-3,5...)
Affinity DataIC50: 10nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2022
Entry Details
US Patent

TargetFibroblast growth factor receptor 3(Human)
Incyte

US Patent
LigandPNGBDBM261978(1-(4-(1H-pyrazol-1-yl)phenyl)- 3-(2,6-difluoro-3,5...)
Affinity DataIC50: 10nMAssay Description:FGFR1, FGFR2, and FGFR4 are measured under equivalent conditions with the following changes in enzyme and ATP concentrations: FGFR1, 0.02 nM and 210 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2018
Entry Details
US Patent

TargetFibroblast growth factor receptor 2(Human)
Incyte

US Patent
LigandPNGBDBM261978(1-(4-(1H-pyrazol-1-yl)phenyl)- 3-(2,6-difluoro-3,5...)
Affinity DataIC50: 10nMAssay Description:FGFR1, FGFR2, and FGFR4 are measured under equivalent conditions with the following changes in enzyme and ATP concentrations: FGFR1, 0.02 nM and 210 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2018
Entry Details
US Patent

TargetFibroblast growth factor receptor 3(Human)
Incyte

US Patent
LigandPNGBDBM261978(1-(4-(1H-pyrazol-1-yl)phenyl)- 3-(2,6-difluoro-3,5...)
Affinity DataIC50: 10nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

TargetFibroblast growth factor receptor 2(Human)
Incyte

US Patent
LigandPNGBDBM261978(1-(4-(1H-pyrazol-1-yl)phenyl)- 3-(2,6-difluoro-3,5...)
Affinity DataIC50: 10nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

TargetFibroblast growth factor receptor 1(Human)
Incyte

US Patent
LigandPNGBDBM261978(1-(4-(1H-pyrazol-1-yl)phenyl)- 3-(2,6-difluoro-3,5...)
Affinity DataIC50: 20nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/10/2021
Entry Details
US Patent

TargetFibroblast growth factor receptor 1(Human)
Incyte

US Patent
LigandPNGBDBM261978(1-(4-(1H-pyrazol-1-yl)phenyl)- 3-(2,6-difluoro-3,5...)
Affinity DataIC50: 20nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2022
Entry Details
US Patent

TargetFibroblast growth factor receptor 1(Human)
Incyte

US Patent
LigandPNGBDBM261978(1-(4-(1H-pyrazol-1-yl)phenyl)- 3-(2,6-difluoro-3,5...)
Affinity DataIC50: 20nMAssay Description:FGFR1, FGFR2, and FGFR4 are measured under equivalent conditions with the following changes in enzyme and ATP concentrations: FGFR1, 0.02 nM and 210 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2018
Entry Details
US Patent

TargetFibroblast growth factor receptor 1(Human)
Incyte

US Patent
LigandPNGBDBM261978(1-(4-(1H-pyrazol-1-yl)phenyl)- 3-(2,6-difluoro-3,5...)
Affinity DataIC50: 20nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

TargetFibroblast growth factor receptor 4(Human)
Incyte

US Patent
LigandPNGBDBM261978(1-(4-(1H-pyrazol-1-yl)phenyl)- 3-(2,6-difluoro-3,5...)
Affinity DataIC50: 115nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/10/2021
Entry Details
US Patent

TargetFibroblast growth factor receptor 4(Human)
Incyte

US Patent
LigandPNGBDBM261978(1-(4-(1H-pyrazol-1-yl)phenyl)- 3-(2,6-difluoro-3,5...)
Affinity DataIC50: 115nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

TargetFibroblast growth factor receptor 4(Human)
Incyte

US Patent
LigandPNGBDBM261978(1-(4-(1H-pyrazol-1-yl)phenyl)- 3-(2,6-difluoro-3,5...)
Affinity DataIC50: 115nMAssay Description:FGFR1, FGFR2, and FGFR4 are measured under equivalent conditions with the following changes in enzyme and ATP concentrations: FGFR1, 0.02 nM and 210 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2018
Entry Details
US Patent

TargetFibroblast growth factor receptor 4(Human)
Incyte

US Patent
LigandPNGBDBM261978(1-(4-(1H-pyrazol-1-yl)phenyl)- 3-(2,6-difluoro-3,5...)
Affinity DataIC50: 115nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2022
Entry Details
US Patent