BDBM261927 1-(cyclopropylmethyl)-3-(2,6-difluoro-3,5-dimethoxyphenyl)-7-(1,3-dimethyl-1H-pyrazol-4-yl)-3,4-dihydropyrido[4,3-d]pyrimidin-2(1H)-one::US10251892, Example 29::US10632126, Example 29::US11173162, Example 29::US9708318, 29

SMILES COc1cc(OC)c(F)c(N2Cc3cnc(cc3N(CC3CC3)C2=O)-c2cn(C)nc2C)c1F

InChI Key InChIKey=REQOBPKMMMACLB-UHFFFAOYSA-N

Data  16 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 16 hits for monomerid = 261927   

TargetFibroblast growth factor receptor 1(Human)
Incyte

US Patent
LigandPNGBDBM261927(1-(cyclopropylmethyl)-3-(2,6-difluoro-3,5-dimethox...)
Affinity DataIC50: 20nMAssay Description:FGFR1, FGFR2, and FGFR4 are measured under equivalent conditions with the following changes in enzyme and ATP concentrations: FGFR1, 0.02 nM and 210 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2018
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 2(Human)
Incyte

US Patent
LigandPNGBDBM261927(1-(cyclopropylmethyl)-3-(2,6-difluoro-3,5-dimethox...)
Affinity DataIC50: 10nMAssay Description:FGFR1, FGFR2, and FGFR4 are measured under equivalent conditions with the following changes in enzyme and ATP concentrations: FGFR1, 0.02 nM and 210 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2018
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 3(Human)
Incyte

US Patent
LigandPNGBDBM261927(1-(cyclopropylmethyl)-3-(2,6-difluoro-3,5-dimethox...)
Affinity DataIC50: 10nMAssay Description:FGFR1, FGFR2, and FGFR4 are measured under equivalent conditions with the following changes in enzyme and ATP concentrations: FGFR1, 0.02 nM and 210 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2018
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 4(Human)
Incyte

US Patent
LigandPNGBDBM261927(1-(cyclopropylmethyl)-3-(2,6-difluoro-3,5-dimethox...)
Affinity DataIC50: 20nMAssay Description:FGFR1, FGFR2, and FGFR4 are measured under equivalent conditions with the following changes in enzyme and ATP concentrations: FGFR1, 0.02 nM and 210 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2018
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 1(Human)
Incyte

US Patent
LigandPNGBDBM261927(1-(cyclopropylmethyl)-3-(2,6-difluoro-3,5-dimethox...)
Affinity DataIC50: 20nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 2(Human)
Incyte

US Patent
LigandPNGBDBM261927(1-(cyclopropylmethyl)-3-(2,6-difluoro-3,5-dimethox...)
Affinity DataIC50: 10nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 3(Human)
Incyte

US Patent
LigandPNGBDBM261927(1-(cyclopropylmethyl)-3-(2,6-difluoro-3,5-dimethox...)
Affinity DataIC50: 10nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 4(Human)
Incyte

US Patent
LigandPNGBDBM261927(1-(cyclopropylmethyl)-3-(2,6-difluoro-3,5-dimethox...)
Affinity DataIC50: 20nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 1(Human)
Incyte

US Patent
LigandPNGBDBM261927(1-(cyclopropylmethyl)-3-(2,6-difluoro-3,5-dimethox...)
Affinity DataIC50: 20nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/10/2021
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 2(Human)
Incyte

US Patent
LigandPNGBDBM261927(1-(cyclopropylmethyl)-3-(2,6-difluoro-3,5-dimethox...)
Affinity DataIC50: 10nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/10/2021
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 3(Human)
Incyte

US Patent
LigandPNGBDBM261927(1-(cyclopropylmethyl)-3-(2,6-difluoro-3,5-dimethox...)
Affinity DataIC50: 10nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/10/2021
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 4(Human)
Incyte

US Patent
LigandPNGBDBM261927(1-(cyclopropylmethyl)-3-(2,6-difluoro-3,5-dimethox...)
Affinity DataIC50: 20nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/10/2021
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 1(Human)
Incyte

US Patent
LigandPNGBDBM261927(1-(cyclopropylmethyl)-3-(2,6-difluoro-3,5-dimethox...)
Affinity DataIC50: 20nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2022
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 2(Human)
Incyte

US Patent
LigandPNGBDBM261927(1-(cyclopropylmethyl)-3-(2,6-difluoro-3,5-dimethox...)
Affinity DataIC50: 10nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2022
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 3(Human)
Incyte

US Patent
LigandPNGBDBM261927(1-(cyclopropylmethyl)-3-(2,6-difluoro-3,5-dimethox...)
Affinity DataIC50: 10nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2022
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 4(Human)
Incyte

US Patent
LigandPNGBDBM261927(1-(cyclopropylmethyl)-3-(2,6-difluoro-3,5-dimethox...)
Affinity DataIC50: 20nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2022
Entry Details
Go to US Patent