BDBM261184 2-(4-(3-(1-(4-amino-3-methyl-1H- pyrazolo[3,4-d]pyrimidin-1- yl)ethyl)-5-chloro-2-methoxy-6- methylphenyl)-1H-pyrazol-1-yl)- N,N-dimethylpropanamide4::US10646492, Example 207::US9707233, 207

SMILES CCOc1c(cc(Cl)c(C)c1-c1cnn(c1)C(C)C(=O)N(C)C)C(C)n1nc(C)c2c(N)ncnc12

InChI Key InChIKey=QTEMHQCQDQARBZ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 261184   

LigandPNGBDBM261184(2-(4-(3-(1-(4-amino-3-methyl-1H- pyrazolo[3,4-d]py...)
Affinity DataIC50: 10nMpH: 6.7 T: 2°CAssay Description:Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2018
Entry Details
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LigandPNGBDBM261184(2-(4-(3-(1-(4-amino-3-methyl-1H- pyrazolo[3,4-d]py...)
Affinity DataIC50: 10nMAssay Description:The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 uL. Inhibitors wer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/25/2021
Entry Details
Go to US Patent