BDBM261166 5-(3-(1-(4-Amino-3-methyl-1H-pyrazolo[3,4-d]pyrimidin-1-yl)ethyl)-5-chloro-2-(2,2-difluoroethoxy)-6-methylphenyl)-N,N-dimethylpicolinamide bis(2,2,2-trifluoroacetate)::US10092570, Example 189::US11433071, Example 189::US9707233, 189::US9730939, Example 189
SMILES CC(Nc1ncnc(N)c1C(C)=N)c1cc(Cl)c(C)c(-c2ccc(nc2)C(=O)N(C)C)c1OCC(F)F
InChI Key InChIKey=CMWVTUXPMJCWRM-UHFFFAOYSA-N
Data 4 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 4 hits for monomerid = 261166
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta/delta isoform(Human)
Incyte Holdings
US Patent
Incyte Holdings
US Patent
Affinity DataIC50: 10nMpH: 6.7 T: 2°CAssay Description:Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Human)
Incyte Holdings
US Patent
Incyte Holdings
US Patent
Affinity DataIC50: 10nMpH: 6.7 T: 2°CAssay Description:[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Human)
Incyte Holdings
US Patent
Incyte Holdings
US Patent
Affinity DataIC50: 10nMAssay Description:[γ-33P]ATP (10 mCi/mL) was purchased from PerkinElmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Human)
Incyte Holdings
US Patent
Incyte Holdings
US Patent
Affinity DataIC50: 10nMAssay Description:The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 μL. Inhibitor...More data for this Ligand-Target Pair