BDBM261156 3-(3-(1-(4-Amino-3-methyl-1H-pyrazolo[3,4-d]pyrimidin-1-yl)ethyl)-5-chloro-2-methoxy-6-methylphenyl)-N-methylpropanamide 2,2,2-trifluoroacetate::US10092570, Example 179::US10376513, Example 179::US10646492, Example 179::US11433071, Example 179::US9707233, 179::US9730939, Example 179

SMILES CNC(=O)CCc1c(C)c(Cl)cc(C(C)n2nc(C)c3c(N)ncnc23)c1OC

InChI Key InChIKey=UIZKSFVGVUNDFB-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 261156   

LigandPNGBDBM261156(3-(3-(1-(4-Amino-3-methyl-1H-pyrazolo[3,4-d]pyrimi...)
Affinity DataIC50: 10nMpH: 6.7 T: 2°CAssay Description:Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2018
Entry Details
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LigandPNGBDBM261156(3-(3-(1-(4-Amino-3-methyl-1H-pyrazolo[3,4-d]pyrimi...)
Affinity DataIC50: 10nMpH: 6.7 T: 2°CAssay Description:[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/18/2019
Entry Details
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LigandPNGBDBM261156(3-(3-(1-(4-Amino-3-methyl-1H-pyrazolo[3,4-d]pyrimi...)
Affinity DataIC50: 10nMAssay Description:[γ-33P]ATP (10 mCi/mL) was purchased from PerkinElmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2019
Entry Details
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LigandPNGBDBM261156(3-(3-(1-(4-Amino-3-methyl-1H-pyrazolo[3,4-d]pyrimi...)
Affinity DataIC50: 10nMAssay Description:[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details
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LigandPNGBDBM261156(3-(3-(1-(4-Amino-3-methyl-1H-pyrazolo[3,4-d]pyrimi...)
Affinity DataIC50: 10nMAssay Description:The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 uL. Inhibitors wer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/25/2021
Entry Details
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LigandPNGBDBM261156(3-(3-(1-(4-Amino-3-methyl-1H-pyrazolo[3,4-d]pyrimi...)
Affinity DataIC50: 10nMAssay Description:The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 μL. Inhibitor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2022
Entry Details
Go to US Patent