BDBM261140 1-{1-[5-Chloro-2-methoxy-4-methyl-3-(1-methylpiperidin-4-yl)phenyl]ethyl}-3-methyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine::US10092570, Example 163::US10376513, Example 163::US10646492, Example 163::US11433071, Example 163::US9707233, 163::US9730939, Example 163::US9932341, Example 163

SMILES COc1c(cc(Cl)c(C)c1C1CCN(C)CC1)C(C)n1nc(C)c2c(N)ncnc12

InChI Key InChIKey=QQLYWGQNVSLCFL-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 261140   

LigandPNGBDBM261140(1-{1-[5-Chloro-2-methoxy-4-methyl-3-(1-methylpiper...)
Affinity DataIC50: 10nMpH: 6.7 T: 2°CAssay Description:Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2018
Entry Details
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LigandPNGBDBM261140(1-{1-[5-Chloro-2-methoxy-4-methyl-3-(1-methylpiper...)
Affinity DataIC50: 10nMpH: 6.7 T: 2°CAssay Description:[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/18/2019
Entry Details
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LigandPNGBDBM261140(1-{1-[5-Chloro-2-methoxy-4-methyl-3-(1-methylpiper...)
Affinity DataIC50: 10nMAssay Description:[γ-33P]ATP (10 mCi/mL) was purchased from PerkinElmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2019
Entry Details
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LigandPNGBDBM261140(1-{1-[5-Chloro-2-methoxy-4-methyl-3-(1-methylpiper...)
Affinity DataIC50: 10nMAssay Description:The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 uL. Inhibitors wer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2020
Entry Details
Go to US Patent

LigandPNGBDBM261140(1-{1-[5-Chloro-2-methoxy-4-methyl-3-(1-methylpiper...)
Affinity DataIC50: 10nMAssay Description:[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details
Go to US Patent

LigandPNGBDBM261140(1-{1-[5-Chloro-2-methoxy-4-methyl-3-(1-methylpiper...)
Affinity DataIC50: 10nMAssay Description:The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 uL. Inhibitors wer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/25/2021
Entry Details
Go to US Patent

LigandPNGBDBM261140(1-{1-[5-Chloro-2-methoxy-4-methyl-3-(1-methylpiper...)
Affinity DataIC50: 11nMAssay Description:Inhibition of PI3Kdelta (unknown origin) using D-myophosphatidylinositol 4,5-bisphosphate as substrate incubated for 120 mins by [gamma-33P]ATP based...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
LigandPNGBDBM261140(1-{1-[5-Chloro-2-methoxy-4-methyl-3-(1-methylpiper...)
Affinity DataIC50: 10nMAssay Description:The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 μL. Inhibitor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2022
Entry Details
Go to US Patent