BDBM260521 US10428074, Example 150::US9527851, 150::US9527851, example 150

SMILES CN([C@@H]1C[C@@H]2CCN(C[C@@H]2C1)C(=O)Nc1nncs1)c1ncnc2[nH]ccc12

InChI Key InChIKey=VSMVCHIPOZPGRW-UHFFFAOYSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 260521   

TargetTyrosine-protein kinase JAK1(Human)
Jiangsu Hengrui Medicine

US Patent
LigandPNGBDBM260521(US9527851, 150 | US9527851, example 150 | US104280...)
Affinity DataIC50: 40nMpH: 7.3 T: 2°CAssay Description:In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK1 kinase. The test ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2017
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK2(Human)
Jiangsu Hengrui Medicine

US Patent
LigandPNGBDBM260521(US9527851, 150 | US9527851, example 150 | US104280...)
Affinity DataIC50: 23nMpH: 7.3 T: 2°CAssay Description:In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK2 kinase. The test ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2017
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK3(Human)
Jiangsu Hengrui Medicine

US Patent
LigandPNGBDBM260521(US9527851, 150 | US9527851, example 150 | US104280...)
Affinity DataIC50: 148nMpH: 7.3 T: 2°CAssay Description:In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK3 kinase. The test ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2017
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK1(Human)
Jiangsu Hengrui Medicine

US Patent
LigandPNGBDBM260521(US9527851, 150 | US9527851, example 150 | US104280...)
Affinity DataIC50: 40nMpH: 7.3 T: 2°CAssay Description:TBDIn vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK1 kinase. The te...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2018
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK2(Human)
Jiangsu Hengrui Medicine

US Patent
LigandPNGBDBM260521(US9527851, 150 | US9527851, example 150 | US104280...)
Affinity DataIC50: 23nMpH: 7.3 T: 2°CAssay Description:In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK2 kinase. The test ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2018
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK3(Human)
Jiangsu Hengrui Medicine

US Patent
LigandPNGBDBM260521(US9527851, 150 | US9527851, example 150 | US104280...)
Affinity DataIC50: 148nMpH: 7.3 T: 2°CAssay Description:TBDIn vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK3 kinase. The te...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2018
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK1(Human)
Jiangsu Hengrui Medicine

US Patent
LigandPNGBDBM260521(US9527851, 150 | US9527851, example 150 | US104280...)
Affinity DataIC50: 40nMAssay Description:JAK1: In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK1 kinase. The...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK2(Human)
Jiangsu Hengrui Medicine

US Patent
LigandPNGBDBM260521(US9527851, 150 | US9527851, example 150 | US104280...)
Affinity DataIC50: 23nMAssay Description:JAK2: In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK2 kinase. The...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK3(Human)
Jiangsu Hengrui Medicine

US Patent
LigandPNGBDBM260521(US9527851, 150 | US9527851, example 150 | US104280...)
Affinity DataIC50: 148nMAssay Description:JAK3: In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK3 kinase. The...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details
Go to US Patent