BDBM259884 US10308662, Compound 125::US9505780, 125

SMILES CCOC(=O)c1ccc(cc1)-c1csc2c1oc(cc2=O)N1CCSCC1

InChI Key InChIKey=SVVHECPUFAEKND-UHFFFAOYSA-N

Data  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 259884   

TargetBromodomain-containing protein 4 [75-147](Human)
Signal Rx Pharmaceuticals

US Patent
LigandPNGBDBM259884(US9505780, 125 | US10308662, Compound 125)
Affinity DataIC50: 1.01E+3nMAssay Description:Several TP Scaffold compounds were tested for inhibition activity against isoforms of PI3K (alpha, beta, gamma, and delta isoforms) and the bromodoma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2017
Entry Details
Go to US Patent

TargetBromodomain-containing protein 4 [368-440](Human)
Signal Rx Pharmaceuticals

US Patent
LigandPNGBDBM259884(US9505780, 125 | US10308662, Compound 125)
Affinity DataIC50: 1.87nMAssay Description:Several TP Scaffold compounds were tested for inhibition activity against isoforms of PI3K (alpha, beta, gamma, and delta isoforms) and the bromodoma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2017
Entry Details
Go to US Patent

LigandPNGBDBM259884(US9505780, 125 | US10308662, Compound 125)
Affinity DataIC50: 2.91E+4nMAssay Description:Several TP Scaffold compounds were tested for inhibition activity against isoforms of PI3K (alpha, beta, gamma, and delta isoforms) and the bromodoma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2017
Entry Details
Go to US Patent

LigandPNGBDBM259884(US9505780, 125 | US10308662, Compound 125)
Affinity DataIC50: 2.49E+3nMAssay Description:Several TP Scaffold compounds were tested for inhibition activity against isoforms of PI3K (alpha, beta, gamma, and delta isoforms) and the bromodoma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2017
Entry Details
Go to US Patent

LigandPNGBDBM259884(US9505780, 125 | US10308662, Compound 125)
Affinity DataIC50: 5.00E+4nMAssay Description:Several TP Scaffold compounds were tested for inhibition activity against isoforms of PI3K (alpha, beta, gamma, and delta isoforms) and the bromodoma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2017
Entry Details
Go to US Patent

TargetBromodomain-containing protein 4 [44-167](Human)
Signal Rx Pharmaceuticals

US Patent
LigandPNGBDBM259884(US9505780, 125 | US10308662, Compound 125)
Affinity DataIC50: 1.01E+3nMAssay Description:Inhibitory activity can be determined routinely using known methods and also from commercial vendors offering this service for kinases and bromodomai...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/15/2020
Entry Details
Go to US Patent

TargetBromodomain-containing protein 4 [349-460](Human)
Signal Rx Pharmaceuticals

US Patent
LigandPNGBDBM259884(US9505780, 125 | US10308662, Compound 125)
Affinity DataIC50: 1.87E+3nMAssay Description:Inhibitory activity can be determined routinely using known methods and also from commercial vendors offering this service for kinases and bromodomai...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/15/2020
Entry Details
Go to US Patent

TargetPhosphatidylinositol 3-kinase regulatory subunit alpha(Human)
Signal Rx Pharmaceuticals

US Patent
LigandPNGBDBM259884(US9505780, 125 | US10308662, Compound 125)
Affinity DataIC50: 2.91E+4nMAssay Description:Inhibitory activity can be determined routinely using known methods and also from commercial vendors offering this service for kinases and bromodomai...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/15/2020
Entry Details
Go to US Patent

LigandPNGBDBM259884(US9505780, 125 | US10308662, Compound 125)
Affinity DataIC50: 2.49E+3nMAssay Description:Inhibitory activity can be determined routinely using known methods and also from commercial vendors offering this service for kinases and bromodomai...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/15/2020
Entry Details
Go to US Patent

LigandPNGBDBM259884(US9505780, 125 | US10308662, Compound 125)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibitory activity can be determined routinely using known methods and also from commercial vendors offering this service for kinases and bromodomai...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/15/2020
Entry Details
Go to US Patent