BDBM259849 US9505766, 53

SMILES Nc1ncnc2n(cc(-c3ccc(Cl)cc3)c12)-c1cccc(\C=C(/C#N)C(=O)N2CCC2)c1

InChI Key InChIKey=LEQFDZQGIRPRQW-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 259849   

TargetTyrosine-protein kinase BTK(Human)
University of California

US Patent
LigandPNGBDBM259849(US9505766, 53)
Affinity DataIC50: 1.50E+3nMT: 2°CAssay Description:Btk (human, full length) was purchased (Invitrogen, catalog number PV3363) and used as specified in the product literature. Btk (2 nM final concentra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2017
Entry Details
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TargetProto-oncogene tyrosine-protein kinase Src(Human)
University of California

US Patent
LigandPNGBDBM259849(US9505766, 53)
Affinity DataIC50: 5.00E+3nMpH: 7.4 T: 2°CAssay Description:Wild-type and S345C mutant cSrc kinase domains were expressed and purified as described (Blair et al., Nat. Chem. Biol., 2007). The purified cSrc kin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2017
Entry Details
Go to US Patent

TargetProto-oncogene tyrosine-protein kinase Src [S345C](Human)
University of California

US Patent
LigandPNGBDBM259849(US9505766, 53)
Affinity DataIC50: 2.50E+3nMpH: 7.4 T: 2°CAssay Description:Wild-type and S345C mutant cSrc kinase domains were expressed and purified as described (Blair et al., Nat. Chem. Biol., 2007). The purified cSrc kin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2017
Entry Details
Go to US Patent